Prevalence of Metabolically-Obese Normal-Weight Worldwide: Systematic Review and Meta-Analysis

Gianella Zulema Zenas-Trujillo, Irma Trujillo-Ramirez, Jesus Maritza Carhuavilca-Torres, Ronald Espiritu Ayala-Mendivil, Victor Juan Vera-Ponce


Background: Obesity causes the loss of body homeostasis and predisposes to the development of disease; some individuals present alterations described even having a normal body mass index (BMI), and these are called thin metabolically obese. The objective was to carry out a systematic review with meta-analysis to determine the prevalence of metabolically-obese normal-weight (MONW) worldwide.

Methods: The search for studies was conducted from May to June 2022 in the EMBASE, PubMed, WOS, and Scopus databases. The purification and ordering of data were carried out using the Excel 2016 program, later a meta-analysis with the Stata version 17 program.

Results: A total of 408,251 people with normal BMI were identified, of whom 78,054 had a metabolic disorder, and the prevalence after the meta-analysis was 26.78% (95% confidence interval: 18.45 - 36.03) with high heterogeneity (I2 = 99.86%).

Conclusion: The findings of the systematic review confirm a high prevalence of MONW worldwide.

J Endocrinol Metab. 2023;13(3):104-113


Systematic review; Metabolically-obese normal-weight; Obesity; Prevalence

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