Triglyceride Glucose-Waist Circumference Is Superior to Other Biochemical Indicators for Diagnosing Prehypertension and Hypertension

Victor Juan Vera-Ponce, Rosa A. Garcia-Lara, Jenny Raquel Torres-Malca, Joan A. Loayza-Castro, Andrea P. Ramirez-Ortega, Fiorella E. Zuzunaga-Montoya, Cori Raquel Iturregui Paucar, Jhony A. De La Cruz-Vargas


Background: In situations with economic issues and limited resources, prevention and early detection of hypertension are essential for its control. Diagnosis and treatment require considerable expenses, which could lead to an incomplete diagnosis and, therefore, a higher prevalence. The aim of this study was to evaluate the usefulness of eight biochemical indices as diagnostic tools for prehypertension and hypertension.

Methods: This is a diagnostic testing study. The variables were hypertension and prehypertension. Among the markers evaluated were triglycerides/high-density lipoprotein cholesterol (HDL-C), cholesterol/HDL-C, low-density lipoprotein (LDL)/HDL-C, visceral adiposity index, lipid accumulation product, the triglyceride-glucose (TyG) index, TyG-waist circumference (TyG-WC), and TyG-body mass index (TyG-BMI). The receiver operating characteristic (ROC) curve analysis was used as a statistical and graphical method to evaluate diagnostic capacity, as well as the area under the curve (AUC) corresponding to each response variable. Sensitivity (Se) and specificity (Sp) were calculated, along with their 95% confidence intervals (95% CIs).

Results: The prevalence of undiagnosed prehypertension and hypertension was 6.88% and 2.72%, respectively. The TyG-WC has been the best indicator for both prehypertension: AUC = 0.712 (95% CI: 0.650 - 0.775), cutoff = 762.56, Se = 90.74 (95% CI: 79.70 - 96.92), and Sp = 45.24 (95% CI: 41.61 - 48.92), in terms of diagnostic capacity. The same applies to hypertension: AUC = 0.801 (95% CI: 0.718 - 0.883), cutoff = 862.57, Se = 81.81 (95% CI: 59.72 - 94.81), and Sp = 70.18 (95% CI: 66.84 - 73.35).

Conclusions: The TyG-WC is the best diagnostic tool for prehypertension and hypertension; hence, it is necessary to conduct prospective research to verify these findings. If confirmed, the TyG-WC can be used as a marker for the prognosis of these two conditions and, thus, to make decisions about prevention.

J Endocrinol Metab. 2023;13(4):135-143


Prehypertension; Hypertension; Waist circumference; Triglycerides; Glucose

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