Thyrotoxic Periodic Paralysis: An Update

Jayanta Chakraborty, Semanti Chakraborty, Rita Moitra


Thyrotoxic periodic paralysis (TPP) is an endocrine emergency. In initial hours, it requires multidisciplinary care as it involves heart and nervous system. Early diagnosis demands highest clinical acumen as symptoms and signs of thyrotoxicosis are often subtle. TPP is not nowadays confined to particular ethnic groups. Different cellular ion channels have been identified in its etiopathogenesis. Definitive treatment of thyrotoxicosis is also important to prevent relapse. In all cases of hypokalemia in emergency room, TPP should be excluded. of hypokalemia should be rationalized to prevent rebound hyperkalemia as total body potassium loss is minimum or nil. Patients should be made euthyroid as soon as possible to prevent relapse of TPP. Future research on ethnic variation of Na+-K+ ATPase activity may enlighten us the cause of higher prevalence in Asians.

J Endocrinol Metab. 2020;10(3-4):60-62


Hypokalemic periodic paralysis; Thyrotoxic periodic paralysis; Graves disease; Na+ - K+ ATPase; Kir2.6 channel (KCNJ18)

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