Evaluation of Age-Specific Efficacy and Safety of 12 Months of Sitagliptin Therapy Administered by Non-Diabetologists

Shouhei Yuasa, Kazuyoshi Sato, Takamoto Furuki, Kosuke Minamizawa, Hiroyuki Sakai, Yuichi Numata, Keiichi Chin, Jisho Kojima, Masaaki Miyakawa, Ikuro Matsuba

Abstract


Background: The mean age of overall incident dialysis patients is 68.9 years for men and 71.4 years for women, and it is increasing yearly, and diabetic nephropathy is the most common underlying disease of it. On the other hand, the number of diabetologist has been insufficient for an ever-increasing number of diabetic patients in Japan. In this context, the examination and treatment of diabetes in non-specialist settings, as well as in specialist settings, have become important.

Methods: A multicenter, retrospective, observational study was conducted in Kanagawa, Japan. Laboratory data were compiled for 1 year at intervals of 3 months following the start of sitagliptin treatment. The subjects were divided into three groups by age: < 65 years (n = 148), 65 - 74 years (n = 134), and >= 75 years (n = 127). Laboratory values in comparison with baseline were compared within groups at various time points, and changes from baseline were compared among the different groups. Participating doctors were not diabetologists.

Results: In the 65 - 74 and >= 75 years of age groups, estimated glomerular filtration rate (eGFR) was decreased significantly from baseline at months 3, 6, 9, and 12, whereas there was no significant decrease from the month-3 value at months 6, 9, or 12. Meanwhile, in the < 65 years of age group, eGFR was decreased significantly from baseline at months 9 and 12, whereas changes at months 3 and 6 were not significant. There were significant differences in the magnitude of eGFR changes among age groups at month 3, but not at months 6, 9, or 12. Hemoglobin A1c (HbA1c) was reduced significantly at month 3, and the reduced level was maintained until month 12 in all age groups.

Conclusions: The efficacy and safety of sitagliptin therapy in the elderly were confirmed in non-specialist settings. These findings will help non-diabetologists choose an appropriate drug in areas where the numbers of diabetic patients and elderly persons are increasing.




J Endocrinol Metab. 2020;10(1):23-29
doi: https://doi.org/10.14740/jem634


Keywords


Type 2 diabetes mellitus; DPP-4 inhibitor; Non-specialist; Elderly; Diabetic nephropathy

Full Text: HTML PDF Suppl1 Suppl2 Suppl3
 

Browse  Journals  

 

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

 

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

 

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

 

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

 

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 
       
 

Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.jofem.org   editorial contact: editor@jofem.org    elmer.editorial2@hotmail.com
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.


Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.