Oscillating Hypothyroidism and Hyperthyroidism: A Rare Autoimmune Syndrome

Gabriel Melki, FNU Komal, Linda Laham, Gres Karim, Vinod Kumar, Sushant Nanavati, Mourad Ismail


Graves disease is an autoimmune thyroid disorder with overproduction of thyroid hormones secondary to the production of thyroid-stimulating hormone receptor (TSH-R) stimulating antibodies (TSAbs). It is very common for Graves disease patients to convert to a hypothyroid state especially in end-stage Graves disease or after iodine ablation. These patients require lifelong thyroxin replacement therapy. In this case report, we describe a rare phenomenon known as oscillating hypo- and hyperthyroidism. In this rare entity of autoimmune endocrine disorder patients with hypothyroidism spontaneously convert to Graves disease.

J Endocrinol Metab. 2019;9(3):77-78
doi: https://doi.org/10.14740/jem583


Graves’ disease; Autoimmune; Oscillating hypothyroidism and hyperthyroidism; Oscillating hypo- and hyperthyroidism

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