Oscillating Hypothyroidism and Hyperthyroidism: A Rare Autoimmune Syndrome

Abstract

Graves disease is an autoimmune thyroid disorder with overproduction of thyroid hormones secondary to the production of thyroid-stimulating hormone receptor (TSH-R) stimulating antibodies (TSAbs). It is very common for Graves disease patients to convert to a hypothyroid state especially in end-stage Graves disease or after iodine ablation. These patients require lifelong thyroxin replacement therapy. In this case report, we describe a rare phenomenon known as oscillating hypo- and hyperthyroidism. In this rare entity of autoimmune endocrine disorder patients with hypothyroidism spontaneously convert to Graves disease.




J Endocrinol Metab. 2019;9(3):77-78
doi: https://doi.org/10.14740/jem583