Polyglandular Autoimmune Syndrome Type IIIB: Hyperthyroidism and Pernicious Anemia, a Reminder of the Past

Ivan E. Ramirez De Oleo, Mateo Mejia Saldarriaga, Michael Silverman, Santiago Thibaud, Luke R. Sponholz


Polyglandular autoimmune syndrome (PAS) refers to the coexistence of at least two different glandular autoimmune diseases. There are several different classes of PAS which involve different organs and present at different age ranges. PAS type IIIB, also known as thyrogastric syndrome, refers to the presence of thyroid autoimmune disease in patients with pernicious anemia. We report a case of a 46-year-old female with Graves disease who presented with pyelonephritis and was found to have severe vitamin B12 deficiency due to pernicious anemia. In patients with autoimmune conditions, it is important to be on the lookout for the development of other forms of autoimmune disease.

J Endocrinol Metab. 2017;7(5):159-161
doi: https://doi.org/10.14740/jem451w


Pernicious anemia; Intrinsic factor; Pancytopenia; Neutropenia; Polyglandular autoimmune syndrome

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