Hypothalamic Dynamics of CD26 Protein in Obese and Fasted Rats

Rafaela F Alponti, Maria I Nogueira, Paulo F Silveira

Abstract


Background: Impaired control of brain functions by CD26 alterations and sensing of unbalanced metabolism could be related in obese and fasting rats. This study aims to search the hypothalamic regions targeted by the alterations of CD26 and cellular activity (Fos) in monosodium glutamate obese (MSG) and food deprived (FD) rats.

Methods: The patterns of distribution of immunoreactivity (ir) of CD26 and Fos were quantified in the hypothalamus.

Results: Compared to control, the CD26-ir increased in the supraoptic and retrochiasmatic nuclei of MSG. CD26-ir and Fos-ir concomitantly decreased in the dorsomedial and retrochiasmatic nuclei of MSG-FD, the paraventricular nucleus of MSG and MSG-FD and in the supraoptic nucleus of FD and MSG-FD, while they exhibited opposite changes in the retrochiasmatic nucleus of FD and MSG, the arcuate and periventricular nuclei of FD, MSG and MSG-FD, the paraventricular and dorsomedial nuclei of FD and the supraoptic nucleus of MSG.

Conclusions: The data provide clear evidences for regional specific alterations of CD26 together with altered cellular activity in the hypothalamus of MSG and FD animals and demonstrate that regulation of CD26 is a hallmark of hypothalamic exposure to metabolic challenges.




 doi:10.4021/jem24w


Keywords


CD26; Fos; Cellular activity; Obesity; Glutamate; Fasting; Brain

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