J Endocrinol Metab
Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc
Journal website http://www.jofem.org

Letter to the Editor

Volume 3, Number 3, June 2013, pages 78-80


Effects of Sitagliptin May Depend on Clinical and Laboratory Data at the Baseline

Hidekatsu Yanaia, b, c

aDepartment of Internal Medicine, National Center for Global Health and Medicine, Kohnodai Hospital, Chiba 272-8516, Japan
bClinical Research Center, National Center for Global Health and Medicine, Kohnodai Hospital, Chiba 272-8516, Japan
cCorresponding author: Hidekatsu Yanai, Department of Internal Medicine and Clinical Research Center, National Center for Global Health and Medicine, Kohnodai Hospital, 1-7-1 Kohnodai, Chiba 272-8516, Japan

Manuscript accepted for publication June 12, 2013
Short title: Effects of Sitagliptin
doi: https://doi.org/10.4021/jem171w

To the Editor▴Top 

We have previously reported that the 6-month sitagliptin treatment significantly reduced HbA1c, body weight in Japanese patients with type 2 diabetes [1]. We also found a negative correlation between changes in body weight and body mass index (BMI) at baseline, and also reported a negative correlation between changes in HbA1c and HbA1c levels at baseline [1].

Kubota A et al reported that the 12 weeks-sitagliptin treatment significantly decreased HbA1c, serum total cholesterol and postprandial triglyceride levels, systolic blood pressure and diastolic blood pressure, and also increased serum creatinine [2]. However, we could not observe significant differences in systolic and diastolic blood pressure, and serum lipid levels, and estimated glomerular filtration rate (e-GFR) between before and after the sitagliptin treatment [1].

The mean ± SD of age (63.3 ± 11.5) in the study by Kubota A et al was younger than that (64.0 ± 14.0) in our study [1, 2]. Aging influences pharmacokinetics and pharmacodynamics. To understand how age influences effects of sitaglitpin, we analyzed data by dividing subjects studied into patients who are 75 years old or older (the elderly group, n = 54) and patients who are 74 years old or younger (the young group, n = 166). Age ranged from 22 to 74 years old and from 75 to 91 years old, and 83 and 32 female patients were included in the young group and the elderly group, respectively. The mean ± SD of age and BMI were 58.0 ± 12.0 years old and 27.0 ± 5.4 kg/m2, and 81.0 ± 5.0 years old and 23.2 ± 4.0 kg/m2 in the young group and the elderly group, respectively. In the young group, sitagliptin significantly reduced plasma glucose levels in addition to reduction in body weight and HbA1c which were observed in the previous study (Table 1) [1]. In the elderly group, sitaglitpin significantly reduced HbA1c, however, did not show a significant reduction of body weight which was observed in the previous study (Table 2) [1].

Table 1.
Click to view
Table 1. Clinical and Biochemical Data Before and After 6 Month-Use of Sitagliptin in 166 People Who are 74 Years Old or Younger
 

Table 2.
Click to view
Table 2. Clinical and Biochemical Data Before and After 6 Month-Use of Sitagliptin in 54 People Who are 75 Years Old or Older
 

Differences in changes in clinical and biochemical data after 6 month-use of sitagliptin between the young group and the elderly group were shown in Table 3. Sitagliptin showed greater decrease of body weight, systolic blood pressure, plasma glucose and HbA1c, and also showed smaller decrease of serum levels of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol, and e-GFR in the young group as compared with the elderly group.

Table 3.
Click to view
Table 3. Differences in Changes in Clinical and Biochemical Data After 6 Month-Use of Sitagliptin Between People Who are 74 Years Old or Younger and People Who are 75 Years Old or Older
 

In conclusion, our previous study and present study demonstrated that effects of sitagliptin may depend on clinical data such as age and BMI and laboratory data such as HbA1c at the baseline.

Acknowledgments

The authors would like to thank Tomoko Kaga, Yukari Takano, Fumi Kawasaki, Yukie Kawamura, and Naomi Inoue at Clinical Research Center, National Center for Global Health and Medicine Kohnodai Hospital, for their technical help. This work was supported by the Grant of National Center for Global Health and Medicine (22-120).


References▴Top 
  1. Yanai H, Adachi H, Hamasaki H, Masui Y, Yoshikawa R, Moriyama S, Mishima S, et al. Effects of 6-month sitagliptin treatment on glucose and lipid metabolism, blood pressure, body weight and renal function in type 2 diabetic patients: a chart-based analysis. J Clin Med Res. 2012;4(4):251-258.
    pubmed
  2. Kubota A, Maeda H, Kanamori A, Matoba K, Jin Y, Minagawa F, Obana M, et al. Pleiotropic effects of sitagliptin in the treatment of type 2 diabetes mellitus patients. J Clin Med Res. 2012;4(5):309-313.
    pubmed


This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Journal of Endocrinology and Metabolism is published by Elmer Press Inc.

 

Browse  Journals  

 

Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

 

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

 

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

 

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

 

Journal of Neurology Research

International Journal of Clinical Pediatrics

 

 
       
 

Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)


This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.jofem.org   editorial contact: editor@jofem.org    elmer.editorial2@hotmail.com
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.


Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.