Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc
Journal website http://www.jofem.org

Letter to the Editor

Volume 3, Number 3, June 2013, pages 78-80


Effects of Sitagliptin May Depend on Clinical and Laboratory Data at the Baseline

Tables

Table 1. Clinical and Biochemical Data Before and After 6 Month-Use of Sitagliptin in 166 People Who are 74 Years Old or Younger
 
Subjects studied (n)Data before 6 month-use of sitagliptinData after 6 month-use of sitagliptinP value
Presented values indicate mean ± S.D. Statistical analyses have been done by the paired T test; e-GFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL-C, low-density lipoprotein-cholesterol; NS, not statistically significant; TG, triglyceride.
Body weight (kg)11071.6 ± 15.270.7 ± 15.5< 0.01
Systolic blood pressure (mmHg)124126.1 ± 15.3124.6 ± 13.2NS
Diastolic blood pressure (mmHg)12471.7 ± 12.272.7 ± 10.6NS
Plasma glucose (mg/dL)154190.9 ± 71.6176.2 ± 67.8< 0.01
Hemoglobin A1c (%)1327.8 ± 1.37.2 ± 1.2< 0.05
Serum LDL-C (mg/dL)129105.8 ± 30.3103.2 ± 28.8NS
Serum TG (mg/dL)144192.7 ± 126.7187.3 ± 136.8NS
Serum HDL-C (mg/dL)13648.9 ± 13.247.7 ± 11.0NS
e-GFR (mL/min./1.73m2)15580.5 ± 24.779.5 ± 25.9NS

 

Table 2. Clinical and Biochemical Data Before and After 6 Month-Use of Sitagliptin in 54 People Who are 75 Years Old or Older
 
Subjects studied (n)Data before 6 month-use of sitagliptinData after 6 month-use of sitagliptinP value
Presented values indicate mean ± S.D. Statistical analyses have been done by the Wilcoxon signed-rank test; e-GFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL-C, low-density lipoprotein-cholesterol; NS, not statistically significant; TG, triglyceride.
Body weight (kg)3056.3 ± 11.855.7 ± 10.8NS
Systolic blood pressure (mmHg)45128.4 ± 16.1126.9 ± 14.6NS
Diastolic blood pressure (mmHg)4565.4 ± 10.265.2 ± 10.0NS
Plasma glucose (mg/dL)42167.2 ± 54.6173.2 ± 65.1NS
Hemoglobin A1c (%)377.3 ± 1.16.8 ± 1.0< 0.05
Serum LDL-C (mg/dL)37101.6 ± 24.3101.9 ± 20.5NS
Serum TG (mg/dL)40126.1 ± 81.5126.0 ± 84.1NS
Serum HDL-C (mg/dL)4155.0 ± 17.553.6 ± 17.7NS
e-GFR (mL/min./1.73m2)4566.5 ± 19.863.2 ± 18.5NS

 

Table 3. Differences in Changes in Clinical and Biochemical Data After 6 Month-Use of Sitagliptin Between People Who are 74 Years Old or Younger and People Who are 75 Years Old or Older
 
People who are 74 years old or youngerPeople who are 75 years old or olderP value
Presented values indicate mean ± S.D. Statistical analyses have been done by the Z test; e-GFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL-C, low-density lipoprotein-cholesterol; NS, not statistically significant; TG, triglyceride.
Body weight (kg)-0.9 ± 3.9-0.6 ± 2.7< 0.001
Systolic blood pressure (mmHg)-1.5 ± 15.3-1.4 ± 23.0< 0.05
Diastolic blood pressure (mmHg)+1.0 ± 12.2-0.2 ± 13.0NS
Plasma glucose (mg/dL)-14.8 ± 68.9+6.0 ± 74.0< 0.05
Hemoglobin A1c (%)-0.6 ± 1.0-0.4 ± 0.7< 0.001
Serum LDL-C (mg/dL)-2.5 ± 26.7-9.0 ± 33.2< 0.05
Serum TG (mg/dL)-5.4 ± 141.2-0.1 ± 44.2NS
Serum HDL-C (mg/dL)-1.2 ± 8.3-1.4 ± 10.1< 0.001
e-GFR (mL/min./1.73m2)-1.0 ± 12.5-3.2 ± 9.4< 0.01