The Development of Central Pontine Myelinolysis in a Type 1 Diabetic Patient With Anti-Insulin Antibody and Similar Clinical Manifestations to Autoimmune Polyglandular Syndrome

Reo Yoshikawa, Akahito Sako, Hiroki Kitagawa, Hidetaka Hamasaki, Tomoka Okubo, Chika Hiraishi, Keigo Suzuki, Shuichi Mishima, Hidekatsu Yanai


Central pontine myelinolysis is a demyelinating disorder, which is commonly associated with the rapid correction of hyponatremia. We repot an 84-year-old type 1 diabetic woman with high level of anti-insulin antibody, who developed central pontine myelinolysis, in spite of a careful correction of hyponatremia. We believe that high level of anti-insulin antibody and similar clinical manifestations to autoimmune polygrandular syndrome such as Candidiasis, hypothyroidism, type 1 diabetes and liver cirrhosis possibly due to autoimmune hepatitis may be associated with the development of central pontine myelinolysis.

J Endocrinol Metab. 2012;2(4-5):181-186


Anti-insulin antibody; Autoimmune polyglandular syndrome; Central pontine myelinolysis; Insulin glulisine; Type 1 diabetes

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