The Development of Central Pontine Myelinolysis in a Type 1 Diabetic Patient With Anti-Insulin Antibody and Similar Clinical Manifestations to Autoimmune Polyglandular Syndrome

Abstract

Central pontine myelinolysis is a demyelinating disorder, which is commonly associated with the rapid correction of hyponatremia. We repot an 84-year-old type 1 diabetic woman with high level of anti-insulin antibody, who developed central pontine myelinolysis, in spite of a careful correction of hyponatremia. We believe that high level of anti-insulin antibody and similar clinical manifestations to autoimmune polygrandular syndrome such as Candidiasis, hypothyroidism, type 1 diabetes and liver cirrhosis possibly due to autoimmune hepatitis may be associated with the development of central pontine myelinolysis.




J Endocrinol Metab. 2012;2(4-5):181-186
doi: https://doi.org/10.4021/jem112w