Video Gaming Reduces Circulating Creatine Levels in Young Male E-Gamers

Bogdan Andjelic, Nikola Todorovic, Jovana Panic, Milan Vranes, Sergej M. Ostojic


Background: No studies so far assessed whether acute video gaming affects creatine metabolism, a metabolic pathway critical in replenishing immediate energy for cells and tissues with high and intermittent energy fluctuations. In this study, we explored whether a single session of prolonged video gaming alters circulating biomarkers of creatine metabolism in young male e-gamers.

Methods: A total of 12 young men (age 25.6 3.8 years) signed an informed consent to volunteer in this quasi-experimental before-after pilot trial. Each participant took part in a single 6-h session of competitive online ranked matches in a popular tactical first-person shooting game.

Results: A 6-h video gaming session resulted in a statistically significant drop in serum creatine levels (from 27.6 7.5 ┬Ámol/L at baseline to 22.9 8.3 ┬Ámol/L at follow-up; P = 0.029). The mean reduction in serum creatine was 4.70 ┬Ámol/L (95% confidence interval (CI): - 2.3 to 11.7), with a moderate-to-large effect size (d = 0.59). Serum creatinine concentrations tended to drop after the gaming session from 88.1 15.5 to 78.2 19.8 ┬Ámol/L (P = 0.077).

Conclusion: Our findings indicate that creatine homeostasis is sensitive to video gaming perhaps owing to more creatine from the circulation utilized as an energy source for active tissues, including the brain.

J Endocrinol Metab. 2024;14(1):59-62


Creatine; Creatinine; E-gaming; Energy metabolism

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