Difficulties in Correction of Recurrent Hypoglycemia in a Patient With a Progressive Course of Malignant Metastatic Insulinoma

Oksana V. Tsygankova, Antonina G. Antipenko, Natalia E. Evdokimova, Ludmila D. Latyntseva, Sabina S. Bairamova, Tatiana I. Batluk


This article describes a clinical observation of a patient with a progressive course of malignant metastatic insulinoma, despite repeated embolization and chemoembolization (CE) of the right and left hepatic arteries with doxorubicin and gemcitabine, with metastatic liver lesion and subsequent increase in the size of secondary foci. The key clinical problem was severe recurrent hypoglycemia, which persisted against the background of massive intravenous (IV) glucose infusions, short-acting somatostatin therapy, and subcutaneous (SC) glucagon injections, which not only was an impediment to the pathogenic cytostatic therapy but also has led to the fatal outcome of the patient.

J Endocrinol Metab. 2020;10(5):140-143
doi: https://doi.org/10.14740/jem666


Severe hypoglycemia; Malignant insulinoma; Pancreatic neuroendocrine tumors; Case report; Chemoembolization of the hepatic arteries; Metastatic liver lesion; Octreotide; Glucagon

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