Nerve Conduction Studies of Peripheral Motor and Sensory Nerves in the Subjects With Prediabetes

Nikhil Rathi, Bharati Taksande, Sunil Kumar


Background: Prediabetes is a condition in which the fasting blood glucose is elevated above normal levels but not high enough to be classified as diabetes mellitus. There is clear association between sensory polyneuropathy and diabetes mellitus. But association of neuropathy in prediabetes is still not clear. Forty years ago, Ellenberg suggested that neuropathy may indeed occur in prediabetes.

Methods: In the present study, we attempted to study the changes in nerve conduction studies in the patients with glucose intolerance, i.e. impaired fasting blood glucose or impaired glucose tolerance in a tertiary care rural hospital. The study included 65 cases (prediabetic) and 65 controls. Nerve conduction studies were performed on right tibial nerve and right sural in lower limb, with surface recording, using the standardized technique.

Results: The compound muscle action potential (CMAP) and nerve conduction velocity (NCV) of right tibial nerve were significantly reduced in the cases as compared to controls and were found to be statistically significant suggesting motor axonal neuropathy. The sensory nerve action potential (SNAP) and NCV of right sural nerve were significantly reduced in the cases as compared to controls which were found out to be statistically significant suggesting that cases had sensory axonal neuropathy.

Conclusion: All the patients of prediabetes should also be screened for neuropathy. We conclude prediabetic stage is risk factor for development of neuropathy, with hyperglycemia being acting via same mechanism as in cases of diabetes. Prediabetes patients are at risk of developing full blown neuropathy. Early metabolic aberrations as seen in impaired glucose tolerance may lead to changes in the nerve conduction.

J Endocrinol Metab. 2019;9(5):147-150


Neuropathy; Prediabetes; Nerve conduction studies

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.