Development and Validation of a Primary Care Tool to Identify Patients With Type 2 Diabetes Mellitus at High Risk of Hypoglycemia-Related Inpatient Admissions

Kurumbian Chandran, Kai Pik Tai, Matthias Paul Han Sim Toh, Francis Wei Loong Phng, Darren Ee-Jin Seah, Christine Xia Wu


Background: Hypoglycemia inpatient admissions are costly and potentially preventable. Using established risk factors for hypoglycemia, we set out to develop a risk-scoring tool using the data from an Asian population.

Methods: In this historical cohort study, we extracted the data of 47,404 type 2 diabetes mellitus (T2DM) patients with complete data based on their last visit in 2012 at selected National Healthcare Group Polyclinics in Singapore. The outcome variable is the occurrence of any hypoglycemia inpatient admission within 6 months from their last visit in 2012. We entered the following potential predictors into a logistic regression model: 1) Age; 2) Largest reduction in glycated hemoglobin within 1 year; 3) Last body mass index; 4) Last estimated glomerular filtration rate; 5) Usage of sulphonylurea and/or insulin; 6) Last glycated hemoglobin; 7) Any previous hypoglycemia inpatient admission in the past 1 year. The relative weightage of predictors were compared, and the model parameters were subsequently converted to a simple risk score (range: 0 to 100).

Results: We found predictors 1 to 5 to be statistically significant for subsequent hypoglycemia inpatient admission. In our study population, based on a sensitivity of 73.8% and a specificity of 73.1%, a cut-off score of 38 was selected. The area under the receiver-operating characteristic curve was 0.809 (CI: 0.763 - 0.855).

Conclusions: A risk score using commonly available clinical data can help to identify those at risk of hypoglycemia inpatient admission with satisfactory level of accuracy. This score needs to be further validated with randomized controlled studies.

J Endocrinol Metab. 2019;9(3):43-50


Hypoglycemia; Primary care; Diabetes

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.