Simultaneous Melatonin Administration Effectively Deprograms the Negative Influence of Neonatal Hypothyroidism on Immature Follicles but not on Mature Follicles and Body and Ovarian Weights

B.P Thakkar, V.M Zala, A.V Ramachandran


Background: The impact of simultaneous melatonin administration on neonatal progmming by hypothyroidism (HPOT + MT) on adult ovarian functions and serum hormone profiles has been evaluated in the Charles foster strain of rats.

Methods: The female neonates were rendered hypothyroid (HPOT) by feeding lactating mothers with 6-propyl 2-thiouracil (PTU) through drinking water and were simultaneously administered with melatonin (MT) (40 g/animal/day) from day 0 to day 21 in the evening at 16:30 hours just prior to lights off.

Results: The experimental animals (HPOT + MT) consistently showed decreased body and ovary weights compared to controls. The total number of follicles was significantly lower in treated animals (HPOT + MT) but was greater than the HPOT group of animals, and both showed significantly decreased number of follicles compared to control rats. There was a significant reduction in the number of antral follicles and corpora lutea and decreased atretic follicles in experimental rats.

Conclusions: It can be concluded from the above results that melatonin is able to nullify the negative influence of hypothyroidism on adult ovarian functions and steroidogenesis to a greater extent.

J Endocrinol Metab. 2011;1(5):220-226


Ovary; Rats; Melatonin; Hypothyroid 

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