Two Cases of Mitochondrial Diabetes in Which Pancreatic Beta-Cell Function and Neuropathy Were Improved by Glucagon-Like Peptide-1 Receptor Agonist Therapy

Midori Minezaki, Ichiro Abe, Monami Koga, Kaoru Sugimoto, Kaori Takeshita, Saori Takahara, Midori Nakagawa, Hideyuki Fujii, Hanako Ohishi, Tadachika Kudo, Kenji Ohe, Toshihiko Yanase, Kunihisa Kobayashi


Mitochondrial diabetes is a refractory type of diabetes mellitus where pancreas beta-cell function attenuates. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) has been reported for pleiotropic effects in addition to effect to glucose tolerance. In animal models, GLP-1RAs were reported to recover mitochondrial function of pancreas beta-cells and increase the growth rate of nerve cells. Our two cases appear to be the first reported cases in the literature of mitochondrial diabetes where GLP-1RAs improved insulin secretion and neuropathy.

J Endocrinol Metab. 2019;9(1-2):33-36


Mitochondrial diabetes; Glucagon-like peptide-1 receptor agonists; Pancreatic beta-cell function; Neuropathy

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