Irisin: As a Therapeutic Target for Metabolic Disorders

Ikram Ullah Khan


During physical activity, muscle expresses a panel of proteins named as myokines which exert beneficial effects on the distant organs of the body. Irisin is a relatively newly discovered myokine mainly secreted by the skeletal muscles. This myokine is a cleavage fragment of a transmembrane protein known as fibronectin domain-containing protein 5 (FNDC5). Irisin is known to have multi-spectrum functions including browning of adipose tissue (BAT), enhancing insulin sensitivity, cognition, osteogenesis and metabolism. Due to these functions, irisin has a wide range of therapeutic effects on obesity, diabetes mellitus, hypertension, cardiovascular diseases, chronic kidney diseases, cancer and dementia. In current, our focus is emphasized upon the therapeutic aspects of irisin and its possible role in the diagnoses of various metabolic disorders.

J Endocrinol Metab. 2018;8(5):87-93


Irisin; FNDC5; Myokine; Obesity; Diabetes; PCOS

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.