Deficient Activity of Mitochondrial Flavine Adenine Dinucleotide-Linked Glycerophosphate Dehydrogenase in Pancreatic Islet Beta Cells as a Determinant of Non-Insulin-Dependent Diabetes Mellitus

Abstract

Extensive experimental investigations in animal models of diabetes mellitus have led to the proposal that a deficient activity of mitochondrial flavine adenine dinucleotide (FAD)-linked glycerophosphate dehydrogenase represents a far-from-uncommon, albeit not invariable, determinant of pancreatic islet B-cell insulin secretory dysfunction. The major aim of the present review is to summarize the results of these investigations and, hence, to encourage further work on the prevalence of this enzymatic defect in the islet B cell of human subjects, especially non-insulin-dependent diabetic patients.




J Endocrinol Metab. 2018;8(2-3):16-26
doi: https://doi.org/10.14740/jem496w