Cushing Syndrome due to Ectopic ACTH Secretion Presenting With Lower Limb Edema and Pulmonary Nocardia Infection: Case Report and Review of the Literature

Marylene Samia El Hayek, Mahmoud Choucair, Asma Arabi


Ectopic ACTH secretion has been described since 1962, but its presentation as only lower limbs edema was rarely described. Symptoms and signs are very similar to Cushing disease, but with a more rapid onset and progression of symptoms. Cushing syndrome presenting as lower limbs edema only has been reported once. We present here a case of a 60-year-old male patient with ectopic ACTH secretion presenting with isolated lower limb edema and developing pulmonary nocardia infection.

J Endocrinol Metab. 2016;6(5):158-161


Ectopic ACTH; Cushing; Nocardia; Limb edema

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