Does Glycogen Accumulation in Pancreatic Islet Beta Cells Play a Minor or Major Role in the Physiology and Pathology of the Insulin Secretory Response to Glucose?

Abstract

The role of beta cell glycogen in the control of glucose homeostasis was recently questioned. This review aims at reminding that glycogen accumulation in insulin-producing pancreatic islet cells was previously proposed to play a role in the phenomenon of beta cell glucotoxicity. The findings recently reported in an article published in Diabetologia do not invalidate the concept mentioned above.




J Endocrinol Metab. 2016;6(4):104-108
doi: http://dx.doi.org/10.14740/jem368w