Glycogenic Hepatopathy With Persistent Hepatomegaly in a Patient With Uncontrolled Type 1 Diabetes

Ravi Kant, Hillary B. Loper, Vipin Verma, Rana Malek, Cinthia B. Drachenberg, Kashif M. Munir


Even though glycogen overloading of the liver was first described as a component of Mauriac syndrome in 1930, glycogenic hepatopathy (GH) is still an under-recognized complication of type 1 diabetes mellitus (T1DM). GH diagnosis is challenging as it is clinically difficult to distinguish GH from steatohepatitis or glycogen storage disease, and liver biopsy is essential for confirmatory diagnosis. GH is usually a transient condition with unknown long-term complications. We present a case of GH with persistent marked hepatomegaly over 5 years despite normalization of liver enzymes in a patient with uncontrolled T1DM.

J Endocrinol Metab. 2015;5(1-2):189-191


Type 1 diabetes mellitus; Glycogenic hepatopathy; Hepatomegaly; Transaminitis

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