Soft Tissue Metastasis of Parathyroid Carcinoma: Description of a Difficult Case

Ana Filipa Martins, Joao Martin Martins, Sonia do Vale, Carl Christofer Juhlin, Lucas Batista, Marco Franco, Dolores Lopez-Presa, Gabriel Miltenberger-Miltenyi


Parathyroid carcinoma is an extremely rare cause of hyperparathyroidism. Histologic diagnosis may be challenging. DAB, male aged 66 was submitted to subtotal gastrectomy because of a localized gastric adenocarcinoma (intestinal type). A mild primary hyperparathyroidism was simultaneously found. Calcium oxalate nephrolithiasis was diagnosed 16 years before. Sonography revealed a nodular lesion in the right lower thyroid pole, while NMR showed a nodular lesion at the left lower thyroid pole. The sestamibi scan found a late image hyperfixation at the right lower pole. Bilateral inferior parathyroidectomy was performed and revealed on both sides adenoma and moderate nuclear polymorphism and no mitotic figures; on the left side a central cystic area was found. Clinical and biochemical cure apparently followed. Six months later a presumed unrelated nodular lesion in the right thigh muscular mass was removed and found to have numerous mitotic figures and immunoreactivity for PTH. A sestamibi scan showed marked hyperfixation in the right leg and PET-FDG-F18 hyperfixated the right quadricipital area. There is evidence for a long standing disease since nephrolithiasis was found some years before. Long standing hyperparathyroidism and increased gastric acid secretion can lead to chronic gastritis, intestinal metaplasia and gastric adenocarcinoma. There is evidence for evolution along bilateral hyperplasia, adenoma and carcinoma since bilateral disease was present and left cystic nonfunctioning lesion was found. Most surprisingly a single metastatic lesion was later found in a very unusual location and this lesion was highly undifferentiated in sharp contrast with the primitive lesion.

J Endocrinol Metab. 2015;5(1-2):184-188


Parathyroid carcinoma; Hyperparathyroidism; Metastasis

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.