Evaluation of Alveolar Bone Mandibular of Rats Obese Induced at Monosodium Glutamate Undergoing Modified Duodenal-Jejunal Bypass Surgery

Francielly Andressa Felipetti, Edson Oliveira Silva, Ana Lucia Carrinho Ayroza Rangel, Carlos Augusto Nassar, Maria Lucia Bonfleur, Sandra Lucinei Balbo, Cassiane Merigo Nascimento, Patricia Oehlmeyer Nassar

Abstract


Background: Obesity is a worldwide epidemic and its prevalence has doubled in recent years. Studies report that obesity may positively or negatively influence on bone mass resulting in formation or resorption. Furthermore, there is evidence suggesting that some obesity surgical treatments can also result in bone resorption. Thus, the aim of this study was to determine the consequences of monosodium glutamate (MSG)-induced obesity and modified duodenal-jejunal bypass (modDJB) surgery on the mandibular alveolar bone of rats.

Methods: A total of 18 rats were divided into CON group (n = 6), MSG group (n = 6) and MDJB group (n = 6). During the first 5 days of life, the CON group received saline injections, and the MSG and MDJB groups received MSG injections to induce obesity. At 90 days, the MDJB group underwent modDJB surgery. After 2 months, all animals were euthanized; the right hemi-mandible was dissected, processed and submitted to histological analysis. The quantification of osteocytes and osteoclasts and the measurement of the distance between cementum enamel junction and bone crest (CEJ-BC) were performed. The data were analyzed and evaluated using ANOVA and Tukey’s tests.

Results: The results showed that MSG-obese rat had a lower mandibular alveolar bone resorption in comparison with the CON group. However, modDJB surgery contributed to the increase of bone resorption.

Conclusions: Based on these results, the present study concluded that this type of induction of hypothalamic obesity was beneficial to the mandibular bone, but modDJB surgery showed malefic effects on this bone.




J Endocrinol Metab. 2014;4(4):93-100
doi: http://dx.doi.org/10.14740/jem237w

Keywords


Obesity; Bariatric surgery; Bone; Mandible

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