Atypical Fracture With Use of Ibandronate and the Role of Bone Scintigraphy on its Early Diagnosis

Josivan Gomes de Lima, Flavia da Costa Fernandes, Alexandre Barbosa Camara de Souza, Antonio Correia dos Santos Junior, Bartira Miridan X. C. R. Reboucas, Natalia Nobrega de Lima, Lucia Helena Coelho Nobrega, Andre Gustavo P. Sousa, Deciara Jacome Torres Medeiros de Mesquita


We report a case of a 49 year-old woman with osteoporosis in treatment with sodium ibandronate 150 mg per week for 5 years that presented leg and knees pain, causing her to stop physical activities. There were no alterations on the physical examination or on plain radiography of legs. A bone scintigraphy with technetium-99m (99mTc) methylene diphosphonate showed a high uptake on the medial third of both femurs and 20 days later, while walking on the street, she fractured her right femur on the position listed above. Even though it is uncommon, bisphosphonates can predispose atypical fractures after a long time of use. It is difficult, though, to predict which patients are going to develop it. This case brings up the question whether bone scintigraphy could be useful as an exam to the early diagnose of atypical fractures on patients using bisphosphonates for a long period of time.

J Endocrinol Metab. 2013;3(3):67-69


Ibandronate; Bone scintigraphy; Atypical fracture; Early diagnosis

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.