Extracorporeal Membrane Oxygenation in Hyperthyroidism-Related Cardiomyopathy: Two Case Reports

Vincent Pong, Chun-Yip Yeung, Ryan Lap-Yan Ko, Hung-Fat Tse, Chung-Wah Siu


Hyperthyroidism-related cardiomyopathy complicated by acute heart failure and shock is a life-threatening condition. Due to the co-occurrence of systemic congestion, left ventricular systolic dysfunction, and reduced systemic vascular resistance, clinical management remains a major challenge in the intensive care unit. Extracorporeal membrane oxygenation (ECMO) provides temporary support in patients with refractory heart failure and cardiogenic shock. We describe two patients with severe hyperthyroidism-related cardiomyopathy. The first patient, a 33-year-old Chinese male, was newly diagnosed to have hyperthyroidism, presenting with thyroid storm and multi-organ failure. The second patient, a 35-year-old Chinese female, had relapsed Graves disease complicated with hyperthyroidism-related cardiomyopathy and atrial fibrillation. Both patients developed acute heart failure and circulatory collapse, necessitating invasive hemodynamic support. They were hemodynamically supported with veno-arterial mode extracorporeal membrane oxygenation (VA-ECMO) and mechanical ventilation, which were successfully weaned off after 4 days. Subsequent echocardiography and cardiac magnetic resonance revealed normalization of the left ventricular ejection function. Hyperthyroidism-related cardiomyopathy with circulatory collapse is often a fatal condition. Given its highly reversible nature, more aggressive initial mechanical circulatory support in the form of VA-ECMO is warranted.

J Endocrinol Metab. 2013;3(1-2):24-28
doi: https://doi.org/10.4021/jem144w


Hyperthyroidism; Cardiomyopathy; Extracorporeal membrane oxygenation

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics


World Journal of Oncology

Gastroenterology Research

Journal of Hematology


Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity


Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research


Journal of Neurology Research

International Journal of Clinical Pediatrics



Journal of Endocrinology and Metabolism, bimonthly, ISSN 1923-2861 (print), 1923-287X (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website: www.jofem.org   editorial contact: editor@jofem.org
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.