Anemia in Spontaneously Type 2 Diabetic Rats With Renal Impairment

Stella Maris Daniele, Juan Carlos Picena, Hector Rodriguez, Silvana Marisa Montenegro, Maria Cristina Tarres, Stella Maris Martinez


Background: The eSS rats display a mild non obese type 2 diabetic syndrome with an insulin resistant state characterized by hyperglycemia, dyslipidemia and hyperinsulinemia. During the first year, eSS male rats exhibit proteinuria as well as alterations in glomerular filtration.

Methods: In this study, some hematological characteristics were evaluated in 12 month-old eSS males compared to eumetabolic Wistar rats, and the renal histology was also studied.

Results: The diabetic rats were found to have fewer erythrocytes and lower values of hemoglobin. In eSS rats, peripheral blood smears showed immature erythrocytes with polychromatophilia and the presence of erythroblasts was also verified. Thickening of the glomerular basement membrane, areas of tubular dilatation and protein cylinders were observed in kidneys of diabetic animals.

Conclusions: Our results suggest that eSS rats develop anemia because of complex influences of metabolic disturbances and diabetic renal damage and that it might provide new opportunities for studying the pathogenesis of this relevant complication of type 2 diabetics.

J Endocrinol Metab. 2012;2(4-5):171-175


Anemia; Type 2 diabetes; Renal disease; Rats

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