Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website http://www.jofem.org |
Original Article
Volume 2, Number 3, June 2012, pages 105-109
Thyroid Volume Predicts Body Mass Index 2 and 6 Years Later
Tables
Variables | Men n = 1,001 | Women n = 1,494 | ||
---|---|---|---|---|
Mean ± SD | n | Mean ± SD | n | |
Thyroid volume (mL) | 14.3 ± 5.5 | 1,001 | 9.6 ± 3.7 | 1,494 |
TSH (mU/L) | 1.7 ± 1.0 | 1,001 | 2.2 ± 1.5 | 1,494 |
Free T4 (pmol/L) | 13.7 ± 1.9 | 1,001 | 14.0 ± 1.9 | 1,494 |
Weight 2 years after inclusion (kg) | 76.3 ± 10.1 | 1,001 | 59.8 ± 9.4 | 1,494 |
Weight 6 years after inclusion (kg) | 78.3 ± 10.6 | 1,001 | 61.8 ± 10.2 | 1,494 |
Weight change (kg) | 2.0 ± 5.1 | 1,001 | 2.1 ± 5.6 | 1,494 |
BMI 2 years after inclusion (kg/m2) | 25.3 ± 2.9 | 1,001 | 22.8 ± 3.3 | 1,494 |
BMI 6 years after inclusion (kg/m2) | 26.0 ± 3.1 | 1,001 | 23.6 ±3 .6 | 1,494 |
BMI change (kg/m2) | 0.7 ± 1.7 | 1,001 | 0.8 ± 2.2 | 1,494 |
Alcohol Consumption (%) | 76.4 | 994 | 51.7 | 1,490 |
Tobacco Consumption (%) | 52.0 | 965 | 28.6 | 1,448 |
2 years | Men | Women | ||
---|---|---|---|---|
Beta | P value | Beta | P value | |
Age (yr) | 0.05 | 0.02 | 0.12 | < 0.001 |
TSH (mU/L) | 0.05 | 0.55 | 0.09 | 0.12 |
Free T4 (pmol/L) | -0.08 | 0.09 | 0.01 | 0.77 |
Thyroid volume (mL) | 0.09 | < 0.001 | 0.09 | < 0.001 |
Alcohol consumption (%) | 0.42 | 0.06 | 0.10 | 0.54 |
Tobacco consumption (%) | 0.38 | 0.04 | 0.30 | 0.12 |
6 years | ||||
Age (yr) | 0.04 | 0.05 | 0.10 | < 0.001 |
TSH (mU/L) | 0.001 | 0.99 | -0.02 | 0.73 |
Free T4 (pmol/L) | -0.07 | 0.17 | 0.004 | 0.94 |
Thyroid volume (mL) | 0.10 | < 0.001 | 0.09 | < 0.001 |
Alcohol consumption (%) | 0.08 | 0.74 | 0.21 | 0.26 |
Tobacco consumption (%) | 0.44 | 0.03 | 0.36 | 0.09 |
First author, year | Sample Size | Country | Gender | Age (yr) | Subjects with thyroid disease | Iodine status | BMI/Weight | Results |
---|---|---|---|---|---|---|---|---|
aMean age in obese/non-obese group; bMean age in monozygotic twins/dizygotic twins/opposite sex twins. | ||||||||
Hegedus, 1983 [1] | 271 | Denmark | Both | 16 - 91 | Excluded | Borderline iodine-deficient | Weight | β = 0.21, P < 0.001 |
Berghout, 1987 [10] | 50 | Netherland | Males | 20 - 70 | Excluded | Iodine-replete | Weight | r = 0.34, P = 0.05 |
Barrere, 2000 [2] | 2987 | France | Both | Women (35 - 60) Men (45 - 60) | Excluded | Borderline iodine-deficient | BMI | Males β = 0.02 (P = 0.0001) Females β = 0.007 (P = 0.005) |
Gomez, 2000 [3] | 268 | Spain | Both | 15 - 70 | Excluded | Iodine-replete | BMI and weight | BMI (r = 0.13, P = 0.02) Weight (r = 0.39, P = 0.0001) |
Semiz, 2001 [5] | 605 | Turkey | Both | 6 – 11 | Not available | Mild-moderate iodine-deficient | BMI and weight | BMI (r = 0.13, P < 0.001) Weight (r = 0.3, P < 0.001) |
Sari, 2003 [8] | 129 | Turkey | Females | 40.5 ±11.4 38.6 ±12.9a | Excluded | Mild-moderate iodine-deficient | BMI and weight | BMI (r = 0.50, P < 0.001) Weight (r = 0.32, P = 0.002) |
Hansen, 2004 [11] | 520 | Denmark twins | Both | 33.7 ±11.7 36.4 ±11.5 33.7 ±11b | Excluded | Borderline iodine-deficient | BMI | Males (r = 0.03, P = 0.003) females (r = 0.02, P < 0.001) |
Boyanov, 2004 [12] | 212 | Bulgaria | Both | 11 - 15 | All euthyroid | Iodine-replete | BMI and weight | BMI (males r = 0.26, females r = 0.16) Weight (males r = 0.35, females r = 0.43) All: P < 0.05 |
Kaloumenou, 2007 [13] | 440 | Greece | Males | 5 - 18 | Not available | Iodine-replete | BMI | r = 0.17, P = 0.023 |