Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access
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Letter to the Editor

Volume 14, Number 2, April 2024, pages 85-88

A Significance of Selective Inhibition of Urate Transporter 1 and Non-Inhibition of Adenosine Triphosphate-Binding Cassette Transporter in Renal Function in a Patient With Advanced Stage Chronic Kidney Disease

Figures

Figure 1.
Figure 1. Renal and intestinal excretion of UA and indoxyl sulfate. ABCG2: ATP-binding cassette transporter G2; GLUT9: glucose transporter 9; IS: indoxyl sulfate; OAT: organic anion transporter; UA: uric acid; URAT1: urate transporter 1; ATP: adenosine triphosphate.
Figure 2.
Figure 2. Change in serum creatinine levels before and after the start of topiroxostat in a diabetic patient who developed CKD stage G4. CKD: chronic kidney disease.
Figure 3.
Figure 3. Effects of dotinurad (a) and topiroxostat (b) on renal and intestinal transport of UA and indoxyl sulfate, and renal function. ABCG2: ATP-binding cassette transporter G2; IS: indoxyl sulfate; UA: uric acid; URAT1: urate transporter 1. ATP: adenosine triphosphate.