Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website https://www.jofem.org |
Original Article
Volume 13, Number 1, February 2023, pages 33-38
The Severity of Bone Loss: A Comparison Between Cushing’s Disease and Cushing’s Syndrome
Tables
ACS (n = 8) | CD (n = 19) | P value | |
---|---|---|---|
Data are presented as mean ± standard error. *P ≤ 0.05. ACS: adrenal-dependent Cushing’s syndrome; CD: Cushing’s disease; BMI: body mass index; ACTH: adrenocorticotropic hormone; DHEA-S: dehydroepiandrosterone sulfate; UFC: urinary free cortisol; 25(OH)D3: 25-hydroxyvitamin D3; PTH: parathyroid hormone: Ca: calcium; P: phosphorus. | |||
Age (years) | 46.5 ± 3.07 | 44.3 ± 0.34 | 0.48 |
Sex (male/female) | 3/5 | 5/14 | 0.16 |
BMI (kg/m2) | 26.32 ± 1.5 | 28.41 ± 0.49 | 0.535 |
ACTH (pg/mL) | 7.43 ± 1.45 | 93.87 ± 4.62 | < 0.01* |
DHEA-S (µg/L) | 86.0 ± 22.96 | 302.9 ± 12.55 | < 0.01* |
UFC (µg/24 h) | 647.5 ± 71.36 | 405.6 ± 31.54 | 0.01* |
Serum cortisol (mmol/L) | 549.5 ± 28.0 | 574.8 ± 15.25 | 0.12 |
25(OH)D3 (nmol/L) | 39.15 ± 6.76 | 38.02 ± 4.43 | 0.578 |
PTH (ng/L) | 49.60 ± 4.98 | 26.10 ± 4.896 | < 0.01* |
Serum Ca (mmol/L) | 2.08 ± 0.25 | 1.97 ± 0.03 | 0.053 |
Serum P (mmol/L) | 1.55 ± 0.25 | 1.67 ± 0.77 | 0.06 |
T-score values | ACS (n = 8) | CD (n = 19) | P value |
---|---|---|---|
*P ≤ 0.05. ACS: adrenal-dependent Cushing’s syndrome; CD: Cushing’s disease. | |||
Normal | 1 (12.5%) | 4 (21.0%) | < 0.01* |
Osteopenia | 2 (25%) | 10 (52.6%) | < 0.001* |
Osteoporosis | 5 (62.5%) | 5 (26.3%) | 0.03* |
ACS | CD | P value | |
---|---|---|---|
Data are presented as mean ± standard deviation. *P ≤ 0.05. ACS: adrenal-dependent Cushing’s syndrome; CD: Cushing’s disease; BMD: bone mineral density. | |||
BMD (g/cm2) | 0.83 ± 0.12 | 0.97 ± 0.32 | 0.011* |
T-score | -2.98 ± 0.16 | -1.91± 0.33 | < 0·01* |