Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website https://www.jofem.org |
Original Article
Volume 12, Number 2, April 2022, pages 66-72
Evaluation of Risk Factors for Malignancy in Patients With Thyroid Nodules
Tables
Malignant nodules (n = 36) | Benign nodules (n = 45) | P value | |
---|---|---|---|
aData were expressed as mean (interquartile range) according to normality of distribution. bData were expressed in parentheses are percentages. cData were expressed as mean ± standard deviation. BMI: body mass index; WC: waist circumference; BFP: body fat percentage; FBG: fasting blood glucose; HOMA-IR: homeostasis model assessment of insulin resistance. | |||
Agea (years) | 36.5 (24.5) | 35 (13.5) | 0.152 |
Sexb | 0.758 | ||
Male | 6 (13.3%) | 6 (16.7%) | |
Female | 30 (86.7%) | 39 (83.3%) | |
Hypertensionb | 7 (19.4 %) | 4 (9.1%) | 0.208 |
Body weightc (kg) | 82.5 ± 18.2 | 76.33 ± 16.43 | 0.122 |
Heighta (m) | 1.6 (0.12) | 1.6 (0.06) | 0.913 |
BMIc (kg/m2) | 31.59 ± 7.09 | 29.22 ± 5.6 | 0.107 |
WCc (cm) | 110.71 ± 16.21 | 102.74 ± 13.25 | 0.021 |
BFPc | 39.96 ± 8.95 | 36.69 ± 11.62 | 0.168 |
Thyroid volumea (mL) | 6.38 (27.41) | 9.03 (14.65) | 0.459 |
Largest dimensiona (cm) | 2.8 (1.48) | 2.54 (1.48) | 0.251 |
FBGa (mg/dL) | 99 (25) | 96.72(45) | 0.704 |
Insulina (µIU/mL) | 13.39 (10.29) | 9.94 (9.05) | 0.032 |
Insulinc (log) | 1.14 ± 0.23 | 1.001 ± 0.25 | 0.020 |
HOMA-IRc | 4.01 ± 1.93 | 2.97 ± 1.57 | 0.014 |
All patients (n = 81) | Malignant nodules (n = 36) | Benign nodules (n = 45) | ||||
---|---|---|---|---|---|---|
r | P value | r | P value | r | P value | |
aCorrelation is significant at the 0.05 level (two-tailed). bCorrelation is significant at the 0.01 level (two-tailed); BMI: body mass index; WC: waist circumference; BFP: body fat percentage; HOMA-IR: homeostasis model assessment of insulin resistance; FBG: fasting blood glucose. | ||||||
Age (log) | 0.29a | 0.01 | 0.18 | 0.290 | 0.43b | 0.003 |
Height (log) | 0.22 | 0.06 | 0.25 | 0.137 | 0.17 | 0.283 |
Weight | 0.41b | 0.001 | 0.34a | 0.044 | 0.54b | 0.001 |
BMI | 0.34b | 0.002 | 0.23 | 0.176 | 0.54b | 0.001 |
WC | 0.26a | 0.026 | 0.191 | 0.280 | 0.37a | 0.015 |
BFP | 0.3a | 0.009 | 0.2 | 0.241 | 0.47b | 0.002 |
HOMA-IR | 0.25a | 0.038 | 0.21 | 0.266 | 0.37a | 0.015 |
Insulin (log) | 0.23 | 0.059 | 0.05 | 0.812 | 0.45b | 0.003 |
FBG (log) | 0.05 | 0.661 | 0.05 | 0.814 | 0.07 | 0.676 |
B | SE | Wald | P value | Odds ratio | 95% CI for odds ratio | ||
---|---|---|---|---|---|---|---|
Lower | Upper | ||||||
HOMA-IR: homeostasis model assessment of insulin resistance; B: estimated coefficient; SE: standard error; CI: confidence interval. Variable(s) entered on step 1 backward Stepwise (Conditional) logistic regression analysis: insulin (Log), waist circumference, homeostasis model assessment of insulin resistance, age (log), body mass index, sex, body fat percentage. | |||||||
HOMA-IR | 0.328 | 0.148 | 4.921 | 0.027 | 1.389 | 1.039 | 1.856 |
Constant | -1.468 | 0.580 | 6.398 | 0.011 | 0.230 |