Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website https://www.jofem.org |
Original Article
Volume 10, Number 3-4, August 2020, pages 89-93
Sodium-Glucose Co-Transporter 2 Inhibitors Increase Serum Level of Total Procollagen Type 1 Amino-Terminal Propeptide and Bone Strength in Japanese Patients With Type 2 Diabetes Mellitus
Tables
Data are expressed as mean ± SD. SD: standard deviation; BMI: body mass index; HbA1c: hemoglobin A1c; DPP4: dipeptidyl peptidase 4. | |
Number of patients | 19 |
Male/female | 16/3 |
Age (years) | 66 ± 12 |
Body weight(kg) | 73.7 ± 10.9 |
BMI (kg/m2) | 26.6 ± 3.2 |
HbA1c (%) | 7.4 ± 1.1 |
Concomitant medication | |
Anti-diabetic drug (n) | |
Biguanide | 6 |
Sulfonylurea | 1 |
Insulin | 1 |
Alpha-glucosidase inhibitor | 5 |
Thiazolidinedione | 3 |
DPP4-inhibitor | 10 |
Lipid-modifying agents (n) | 13 |
Antihypertensive drug (n) | 13 |
Before administration | After 6 months’ administration | |
---|---|---|
Data are expressed as mean ± SD. *P < 0.05, **P < 0.01 vs. before administration. SD: standard deviation; BMI: body mass index; HbA1c: hemoglobin A1c; SGLT2: sodium-glucose co-transporter 2; LDL: low-density lipoprotein; HDL: high-density lipoprotein. | ||
Body weight (kg) | 73.7 ± 10.9 | 70.6 ± 11.2** |
BMI (kg/m2) | 26.6 ± 3.2 | 25.5 ± 3.2** |
HbA1c (%) | 7.4 ± 1.1 | 6.8 ± 0.8* |
Blood glucose (mg/dL) | 115 ± 36 | 98 ± 17* |
Serum total cholesterol (mg/dL) | 190 ± 30 | 187 ± 23 |
Serum LDL-cholesterol (mg/dL) | 112 ± 26 | 111 ± 20 |
Serum HDL-cholesterol (mg/dL) | 52 ± 10 | 59 ± 9** |
Serum triglyceride (mg/dL) | 186 ± 94 | 117 ± 67** |
Before administration | After 6 months’ administration | |
---|---|---|
Data are expressed as mean ± SD. *P < 0.05 vs. before administration. Bone strength and density are expressed as the comparison with those in young adult means. QUS: quantitative ultrasound; DEXA: dual-energy X-ray absorptiometry; SD: standard deviation; SGLT2: sodium-glucose co-transporter 2. | ||
Bone strength measured by QUS | ||
Calcaneal bone (%) | 88 ± 16 | 91 ± 15* |
Bone density measured by DEXA | ||
Lumbar spine (%) | 109 ± 13 | 106 ± 12 |
Femur (%) | 87 ± 13 | 83 ± 10 |
Serum total P1NP (µg/L) | 35.2 ± 10.3 | 39.0 ± 12.8* |
Serum TRACP-5b (mU/dL) | 215 ± 62 | 245 ± 82 |