Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc
Journal website http://www.jofem.org

Original Article

Volume 9, Number 4, August 2019, pages 90-94


Dapagliflozin Add-On Therapy Improves Body Composition and Metabolic Parameters in Overweight Type 2 Diabetic Patients: A Pilot Study

Tables

Table 1. Baseline Characteristics of Two Groups
 
Group A: metformin+ insulin (n = 25)Group B: metformin (n = 31)
The difference was not significant for each variable. ASA: acetylsalicylic acid; BMI: body mass index; WC: waist circumference; FPG: fasting plasma glucose; TC: total cholesterol; HDL: high-density lipoprotein; TG: triglycerides; Hct: hematocrit; eGFR: estimated glomerular filtration rate; AER: albumin excretion rate; BUN: blood urea nitrogen; AST: aspartate transaminase; ALT: alanine transaminase; FM: fat mass; FFM: fat free mass; TBW: total body water; ECW: extra-cellular water; pA: phase angle.
Age (years)56 ± 10.860 ±11
Diabetes duration (years)16 ± 315 ± 2
Antiplatelets (ASA)22/2526/31
Statins23/2527/31
Antihypertensive drugs24/2528/31
Weight (kg)90.7 ± 13.190.4 ± 12.4
BMI (kg/m2)34.4 ± 8.331.2 ± 4.5
WC (cm)111.1 ± 18.5110.3 ± 13
FPG (mg/dL)179 ± 65168 ± 35
HbA1c (mmol/mol)74 ± 11.8 (8.9±1.9%)66 ± 6.2 (8.2±1%)
TC (mg/dL)174.4 ± 35.1186.7 ± 56.4
HDL (mg/dL)48.3 ± 19.750.0 ± 18
TG (mg/dL)156.0 ± 123.2182.7 ± 67.5
Creatinine (mg/dL)0.8 ± 0.20.9 ± 0.2
Hct (%)41 ± 3.040 ± 3.4
eGFR (mL/min/1.73 m2)82.4 ± 23.483.7 ± 20.3
AER (µg/min)56 ± 12.249.0 ± 11.9
BUN (mg/dL)31.2 ± 7.133.5 ± 12.9
AST (U/L)23.9 ± 6.121.5 ± 3.8
ALT (U/L)25 ± 8.824.2 ± 5.9
FM (kg)30.5 ± 7.930.0 ± 6.2
FFM (kg)60.2 ± 5.260.4 ± 6.2
TBW (L)42.2 ± 743.1 ± 4.4
ECW (L)39.1 ± 439.2 ± 4.1
pA (°)5.3 ± 0.85.2 ± 0.7

 

Table 2. Anthropometric, Biochemical and Bioelectrical Measures of the Two Groups at T0 and T1 After 16 Treatment Weeks
 
Group A: metformin + insulin (n = 25)Group B: metformin (n = 31)
T0T1P-valueT0T1P-value
BMI: body mass index; WC: waist circumference; FPG: fasting plasma glucose; TC: total cholesterol; HDL: high-density lipoprotein; TG: triglycerides; Hct: hematocrit; eGFR: estimated glomerular filtration rate; AER: albumin excretion rate; BUN: blood urea nitrogen; AST: aspartate transaminase; ALT: alanine transaminase; BIA: bioelectrical impedance analysis; FM: fat mass; FFM: fat free mass; TBW: total body water; ECW: extra-cellular water; pA: phase angle.
Age (years)56 ± 10.860 ± 11
Weight (kg)90.7 ± 13.188.2 ± 16.3< 0.000190.4 ± 12.487.0 ± 13.6< 0.0001
BMI (kg/m2)34.4 ± 8.333.4 ± 8.2< 0.000131.2 ± 4.530 ± 3.4< 0.0001
WC (cm)111.1 ± 18.5108.9 ± 18.7< 0.0001110.3 ± 13107.5 ± 12.9< 0.0001
FPG (mg/dL)179 ± 65136 ± 490.007168 ± 35139 ± 24< 0.0001
HbA1c (mmol/mol)74 ± 11.8 (8.9±1.9%)64 ± 10.5 (8.0±1.7%)< 0.000166 ± 6.2 (8.2±1%)56 ± 5.58 (7.3±0.9%)< 0.0001
TC (mg/dL)174.4 ± 35.1161 ± 31.7ns186.7 ± 56.4177 ± 45.3ns
HDL (mg/dL)48.3 ± 19.749.2 ± 18.1ns50.0 ± 1851.5 ± 18.6ns
TG (mg/dL)156.0 ± 123.2133.3 ± 123.80.002182.7 ± 67.5149.8 ± 54.90.002
Hct (%)41 ± 3.041 ± 2.9ns40 ± 3.441 ± 3.0ns
Creatinine (mg/dL)0.8 ± 0.20.8 ± 0.1ns0.9 ± 0.20.8 ± 0.2ns
eGFR (mL/min/1.73 m2)82.4 ± 23.487.8 ± 16.9ns83.7 ± 20.388.5 ± 22.1ns
AER (µg/min)56 ± 12.242 ± 11ns49.0 ± 11.936 ± 11.2ns
BUN (mg/dL)31.2 ± 7.132.1 ± 9.8ns33.5 ± 12.933 ± 12.8ns
AST (U/L)23.9 ± 6.124.1 ± 6.8ns21.5 ± 3.821.9 ± 3.6ns
ALT (U/L)25 ± 8.823.2 ± 9.3ns24.2 ± 5.922.1 ± 6ns
BIA
  FM (kg)30.5 ± 7.928.2 ± 8.2< 0.00130.0 ± 6.226.4 ± 7.0< 0.001
  FFM (kg)60.2 ± 5.259.5 ± 8.1ns60.4 ± 6.259.3 ± 6.6ns
  TBW (L)42.2 ± 740.6 ± 7.9ns43.1 ± 4.440.9 ± 4.9ns
  ECW (L)39.1 ± 437.3 ± 3ns39.2 ± 4.135.7 ± 4.20.021
  pA (°)5.3 ± 0.85.5 ± 0.5ns5.2 ± 0.75.6 ± 0.6ns