| Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
| Journal website http://www.jofem.org |
Case Report
Volume 9, Number 1-2, April 2019, pages 33-36
Two Cases of Mitochondrial Diabetes in Which Pancreatic Beta-Cell Function and Neuropathy Were Improved by Glucagon-Like Peptide-1 Receptor Agonist Therapy
Tables
| Patient 1 | Patient 2 | |
|---|---|---|
| CPI: fasting C-peptide/fasting blood glucose × 100; eGFR: estimated glomerular filtration rate. | ||
| Gender | Female | Female |
| Age (years) | 36 | 44 |
| Duration of diabetes mellitus (years) | 9 | 24 |
| BMI (kg/m2) | 25.9 | 15.9 |
| Fasting plasma glucose (mg/dL) | 119 | 163 |
| HbA1c (%) | 8.1 | 8.8 |
| Serum C-peptide (ng/dL) | 0.91 | 0.39 |
| CPI | 1.08 | 0.24 |
| Urinary C-peptide (µg/day) | 26.0 | 13.5 |
| Diabetic complication | Only neuropathy | Only neuropathy |
| Systolic blood pressure (mm Hg) | 163 | 98 |
| Diastolic blood pressure (mm Hg) | 98 | 60 |
| LDL-cholesterol (mg/dL) | 110 | 105 |
| HDL-cholesterol (mg/dL) | 37 | 51 |
| Triglyceride (mg/dL) | 129 | 62 |
| AST (U/L) | 16 | 14 |
| ALT (U/L) | 10 | 10 |
| γ-GTP (U/L) | 26 | 20 |
| eGFR (mL/min/1.73m2) | 105.7 | 92.5 |
| Na (mmol/L) | 137 | 139 |
| K (mmol/L) | 3.7 | 3.6 |
| Cl (mmol/L) | 110 | 109 |
| Lactate (mg/dL) | 18 | 31 |
| Pyruvate (mg/dL) | 0.89 | 0.82 |
| Lactate/pyruvate | 20.2 | 37.8 |
| Diabetic treatment | Insulin | Insulin |
| Daily insulin dose (unit) | 42 | 41 |
| Vibration sensation of legs (s: right/left) | 8/9 | 4/6 |
| Symptom of neuropathy | Numbness | Numbness and pain |
| Familial history of mitochondrial disorder | MELAS (mother) | Not revealed |
| Before commencing liraglutide | One year after commencing liraglutide | |
|---|---|---|
| CPI: fasting C-peptide/fasting blood glucose × 100. | ||
| Patient 1 | ||
| Fasting plasma glucose (mg/dL) | 119 | 114 |
| HbA1c (%) | 8.1 | 7.4 |
| CPI | 1.08 | 1.27 |
| Daily insulin dose (unit) | 42 | 15 |
| Daily liraglutide dose (mg) | 0 | 0.9 |
| Vibration sensation of legs (s: right/left) | 8/9 | 13/13 |
| Symptom of neuropathy | Numbness | None |
| Patient 2 | ||
| Fasting plasma glucose (mg/dL) | 163 | 111 |
| HbA1c (%) | 8.8 | 8.2 |
| CPI | 0.24 | 0.49 |
| Daily insulin dose (unit) | 41 | 14 |
| Daily liraglutide dose (mg) | 0 | 0.9 |
| Vibration sensation of legs (s: right/left) | 4/6 | 8/8 |
| Symptom of neuropathy | Numbness and pain | Slight pain |