Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website http://www.jofem.org |
Original Article
Volume 7, Number 6, December 2017, pages 172-177
The Impact of Vitamin D Status on Preoperative Ultrasound Findings and Parathyroidectomy Outcomes in Patients With Primary Hyperparathyroidism
Figure
Tables
Variable | Pre-operative | Post-operative | P value |
---|---|---|---|
All data expressed as mean ± standard deviation. | |||
Age (years) | 64.2 ± 11.7 | - | |
Sex (M/F) | 16/65 | - | |
Duration of stay (days) | 4.3 ± 2.9 | - | |
Parathormone (pmol/L) | 15.2 ± 10.9 | 5.6 ± 2.4 | < 0.00001 |
Calcium (mmol/L) | 2.8 ± 0.2 | 2.3 ± 0.2 | < 0.00001 |
Adjusted calcium (mmol/L) | 2.9 ± 0.2 | 2.4 ± 0.1 | < 0.00001 |
Phosphate (mmol/L) | 0.8 ± 0.2 | 1.1 ± 0.2 | < 0.00001 |
Alkaline phosphatase (U/L) | 105.9 ± 42.8 | 88.3 ± 29.5 | < 0.00001 |
Creatinine (µmol/L) | 74.2 ± 21.9 | 76.6 ± 24.3 | 0.01 |
eGFR (mL/min/1.73 m2) | 75.4 ± 13.4 | 76.2 ± 14.6 | 0.24 |
TSH (mU/L) | 1.8 ± 1.1 | - | |
FT4 (pmol/L) | 15.3 ± 2.6 | - | |
Vitamin D (nmol/L) | 36.9 ± 19.7 | - |
Vitamin D status (nmol/L) | < 30 (deficient), n = 36 | ≥ 30 and < 50 (insufficient), n = 27 | ≥ 50 (sufficient), n = 18 |
---|---|---|---|
Single gland disease (SGD) | |||
Right superior gland | 1 (2.8%) | 1 (3.7%) | 1 (5.5%) |
Left superior gland | 0 (0.0%) | 2 (7.4%) | 0 (0.0%) |
Right inferior gland | 7 (19.4%) | 4 (14.8%) | 8 (44.5%) |
Left inferior gland | 12 (33.4%) | 8 (29.6%) | 1 (5.5%) |
No gland involvement | 16 (44.4%) | 12 (44.5%) | 8 (44.5%) |
Multiple gland disease (MGD) | 0 | 0 | 0 |
Diagnosis test | Histology | Sensitivity | Specificity | PPV | NPV | |||
---|---|---|---|---|---|---|---|---|
Positive | Negative | |||||||
All value in brackets are expressed as percentages. | ||||||||
All patients | USS | Positive | 45 (55.5) | 0 (0) | 58.4% | 100% | 100% | 11.1% |
Negative | 32 (39.5) | 4 (5.0) | ||||||
Vitamin D | ||||||||
Deficient | USS | Positive | 20 (55.5) | 0 (0) | 57.1% | 100% | 100% | 6.2% |
Negative | 15 (41.7) | 1 (2.8) | ||||||
Insufficient | USS | Positive | 15 (55.5) | 0 (0) | 62.5% | 100% | 100% | 25.0% |
Negative | 9 (33.3) | 3 (11.2) | ||||||
Sufficient | USS | Positive | 10 (55.5) | 0 (0) | 55.8% | 100% | 100% | 12.5% |
Negative | 7 (38.9) | 1 (5.6) |
Vitamin D status (nmol/L) | < 30 (deficient), n = 36 | ≥ 30 and < 50 (insufficient), n = 27 | ≥ 50 (sufficient), n = 18 | P value |
---|---|---|---|---|
Single gland removed | 21 | 18 | 16 | |
Weight of gland (g) | 1.42 ± 1.35 | 1.11 ± 1.39 | 0.58 ± 0.48 | 0.10 |
Histology | ||||
Benign adenoma | 15 (71.4%) | 14 (77.8%) | 14 (87.5%) | |
Chief cell adenoma | 6 (28.6%) | 1 (5.5%) | 0 (0%) | |
Others (normal, hyperplasia) | 0 (0%) | 3 (16.7%) | 2 (12.5%) | |
Multiple gland removed | 15 | 9 | 2 | |
Combined weight of glands (g) | 1.81 ± 2.79 | 0.93 ± 0.58 | 0.59 ± 0.33 | 0.55 |
Mean number of gland excised | 2.46 ± 1.00 | 2.55 ± 1.00 | 3.50 ± 0.70 | 0.28 |
Histology | ||||
Benign adenoma | 14 (93.3%) | 6 (66.7%) | 2 (100%) | |
Chief cell adenoma | 0 (0%) | 0 (0%) | 0 (0%) | |
Others (normal, hyperplasia) | 1 (6.7%) | 3 (33.3%) | 0 (0%) |