Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc
Journal website http://www.jofem.org

Review

Volume 7, Number 2, April 2017, pages 45-54


The Effect of Growth Hormone Treatment on Adult Height of Children With Idiopathic Short Stature: A Systematic Review and Meta-Analyses

Figures

Figure 1.
Figure 1. The flowchart stages of entering the articles into meta-analysis.
Figure 2.
Figure 2. Mean score of participants’ treatment start age.
Figure 3.
Figure 3. Mean score of height before treatment start.
Figure 4.
Figure 4. Mean score of height after treatment.
Figure 5.
Figure 5. The effect of treatment duration on the final height.
Figure 6.
Figure 6. The effect of received dose on the final height increase.
Figure 7.
Figure 7. Relationship between treatment duration and final height increase.
Figure 8.
Figure 8. Relationship between the consumed dose and increase in final height.
Figure 9.
Figure 9. Begg’s funnel plot.

Table

Table 1. Characteristics of Studies Qualified for Meta-Analysis Review
 
Author, publication year, referenceType designCountryContinentNo. of patientMean age startSD of ageMean height startSD of heightGrowth hormone doseMean durationAdult height MSDAdult height SDEstimate height gainP-value
Bernasconi et al, 1997 [15]CohortItalyEurope71120.2-2.60.10.0354.2-1.690.070.910.05
Hintz et al, 1999 [16]Non-controlled trialUSANorth America8010.11.9-2.70.50.0435.7-20.50.7-
Kemp et al, 2005 [17]CohortUSANorth America30310.52.7-2.90.60.0447-1.30.71.6-
Wit et al, 2005 [11]Non-controlled trialNetherlandEurope5010.10.21-3.20.70.0446.5-2.40.720.80.025
Counts et al, 2013 [18]Non-controlled trialUSANorth America2678.60.34-1.70.330.0522-0.550.081.150.0001
Kim et al, 2014 [19]Non-controlled trialSouth KoreaAsia258.11.9-2.40.540.370.5-1.830.60.570.05
Sotos and Tokar, 2014 [20]CohortUSANorth America8811.992.83-2.60.620.044.8-0.710.741.90.0001
Aviles Espinoza, et al 2016 [21]Non-controlled trialChileSouth America1811.61.2-2.10.850.0331.7-1.640.690.470.0001
Ismail et al, 2011 [22]Non-controlled trialEgyptAfrica219.93.3-3.71.10.0523.5-2.60.91.10.0001
Lee et al, 2012 [23]CohortUSANorth America33410.92.9-2.30.80.052-1.640.840.001
McCaughey et al, 1998 [24]Randomized control trialUKEurope86.240.38-2.50.260.046.2-1.141.061.380.008
Leschek et al, 2004 [25]Randomized control trialUSANorth America2212.51.6-2.70.60.034.4-1.770.80.930.04
Albertsson-Wikland et al, 2008 [10]Randomized control trialSwedenEurope4911.51.3-2.80.560.0545.6-1.60.681.240.001
Wit et al, 1995 [26]Non-randomized control trialNetherlandEurope129.21.6-2.80.70.025.7-2.40.91.40.002
Hindmarsh and Brook, 1996 [27]Non-randomized control trialUKEurope168.351.88-2.20.580.037.5-1.330.940.840.03
Lopez-Siguero et al, 1996 [28]Non-randomized control trialSpainEurope2011.41.3-2.80.520.0255.3-1.460.71.34-
Buchlis et al, 1998 [29]Non-randomized control trialUSANorth America3611.92.8-2.90.60.043.5-1.51.41.40.001
Lopez-Siguero et al, 2000 [30]Non-randomized control trialSpainEurope3511.11.4-2.90.50.025.3-1.310.71.470.04
Coutant et al, 2001 [31]Non-randomized control trialFranceEurope3211.72-30.670.023.9-2.10.760.90.01
Wit and Rekers-Mombarg, 2002 [32]Non-randomized control trialNetherlandEurope3010.72.2-3.30.50.0345.9-1.90.91.40.04