Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc
Journal website http://www.jofem.org

Original Article

Volume 4, Number 4, August 2014, pages 101-109

Autoimmune Polyglandular Syndrome Type II: Epidemiological, Clinical and Immunological Data

Figures

Figure 1.
Figure 1. (A) Frequency of autoimmune endocrine diseases in 106 patients with APS II. (B) Frequency of autoimmune non-endocrine diseases in 106 patients with APS II.
Figure 2.
Figure 2. Most frequent combinations of endocrine component diseases in 106 patients with APS II. Only the patients with two diseases were noted. Adrenal: Addison’s disease; Thyroid: autoimmune thyroid disease; Diabetes: type I diabetes; Gonad: gonadal failure; POF: premature ovarian failure; Pern.A: pernicious anemia; GJS: Sjogren’s syndrome; Celiac: celiac disease; AH: autoimmune hepatitis; AT: autoimmune thrombocytopenia.
Figure 3.
Figure 3. Time interval between manifestation of first (abscissa) and second endocrine component diseases (ordinate) in 106 patients with APS II. Medians, first and third quartiles as well as ranges of time (months) between manifestation of first and further diseases are shown.
Figure 4.
Figure 4. Age at manifestation of the three main component autoimmune endocrinopathies in 106 patients with APS II.
Figure 5.
Figure 5. The result of cluster analysis showing clinical subgroups of patients with APS II.

Tables

Table 1. Prevalence of Component Disease in APS II
 
DiseasesPresent study (106 cases)Dittmar and Kahaly [12] (151 cases)Weyermann et al [13] (31 cases)
Thyroid (%)93.465.597
Type 1 DM (%)62.360.935
Addison (%)36.818.523
Gonadal failure (%)11.35.316.1
Hypophysitis (%)5.600
Vitiligo (%)5.619.919.3
Alopecia (%)2.860
Sjogren’s syndrome (%)2.800
Pernicious anemia (%)1.85.316.1
Celiac disease (%)1.800
Autoimmune hepatitis (%)0.900
Immune thrombocytopenia (%)0.900

 

Table 2. Prevalence of Positive Autoantibodies in APS II
 
Autoantibodies againstPresent study (106 cases)Dittmar and Kahaly [12] (151 cases)
TPO (%)67.678
TSH-R (%)5848
Tg (%)43.350
Parietal gastric cell (%)-54
GAD (%)51.851
ICA (%)5.623
Insulin (%)-42
Adrenal cortex (%)9.726
Ovarian (%)8.8-