Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
Article copyright, the authors; Journal compilation copyright, J Endocrinol Metab and Elmer Press Inc |
Journal website http://www.jofem.org |
Case Report
Volume 2, Number 3, June 2012, pages 139-144
The Effects of Supraphysiologic Doses of Vitamin D3 in Conjunction With Teriparatide on Bone Mineral Density in Two Postmenopausal Females With Severe Osteoporosis
Tables
Time (months) | Serum 25-hydroxyvitamin D (nmol/L) Reference range: 35 - 150 | Serum calcium (mmol/L) Reference range: 2.05 - 2.55 | Serum phosphorus (mmol/L) Reference range: 0.775 - 1.518 | Serum PTH, intact (ng/L) Reference range: 10 - 65 | Urine cross-linked N-telopeptide (nmol BCE/mmol creat) Reference range: 5 - 65 |
---|---|---|---|---|---|
*Laboratory values for patient 1; ** Laboratory values for patient 2. | |||||
0* | 39.93 | 2.125 | 0.710 | 65 | 75 |
12* | 504.19 | 2.425 | 0.936 | 16 | 90 |
24* | 394.36 | 2.325 | 0.839 | 22 | 64 |
0** | 29.95 | 2.075 | 0.678 | 71 | 50 |
12** | 304.51 | 2.50 | 0.969 | 15 | 86 |
24** | 284.54 | 2.425 | 0.904 | 24 | 64 |
Patient 1 | Patient 2 | |
---|---|---|
BMD, L1-L4 (g/cm2), baseline | 0.393 | 0.351 |
BMD, L1-L4 (g/cm2), at 24 months | 0.582 | 0.639 |
T-score, L1-L4, baseline | -5.9 | -6.3 |
T-score, L1-L4, at 24 months | -4.2 | -3.7 |
% change in BMD, L1-L4, at 24 months | 48.2% | 82.3% |
Absolute increase in BMD at 24 months (g/cm2) | 0.189 | 0.288 |
Patients treated with teriparatide and physiologic doses of vitamin D | Patient#1 | Patient#2 | |
---|---|---|---|
aResults from Eli Lilly pharmaceutical clinical trial. The safety and efficacy of once-daily teriparatide and physiologic doses of vitamin D with a median exposure of 19 months were examined in a double-blind, multicenter, placebo-controlled clinical trial of 1,637 postmenopausal women with osteoporosis [2]. | |||
Percent Change in BMD at the Lumbar Spine over 24 months | 9.7% | 48.2% | 82.3% |
Absolute increase in g/cm2 over 24 months | - | 0.189 | 0.288 |